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According to LSR, NFL teams combined for 791 points—tying 2012 for the highest opening-week total ever—while setting Week 1 records for total touchdowns (93), offensive touchdowns (90), and rushing touchdowns (37). Favorites went 12-4 straight up, while the Over hit in nine of 16 games (9-6-1).

At Caesars Sportsbook, seven of eight early afternoon favorites won outright, and six games went Over the total—many hitting the mark by halftime.

Joey Feazel, head of football at Caesars Sportsbook, told Casino.org that favorites, Overs, and anytime touchdown scorers combined to create a bettor-friendly trifecta. Bettors only faced major resistance when the Los Angeles Chargers were upset by the Arizona Cardinals.

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“But after yesterday’s game, they’re going to draw a lot more support because they were pretty good underdogs (against the Chargers),” Scucci added.

Bettors had plenty of momentum after favorites dominated Week 1, but Sunday (Sept. 20) tilted back in the sportsbooks’ favor behind a wave of upsets. Several heavily backed teams failed to win or cover the spread.

The biggest wins for Boyd were the Eagles failing to cover (24-20 over the Titans), the Saints winning outright as large underdogs (24-17 over the Ravens), and the Browns topping the Bucs (23-19). For bettors looking to recoup losses, the afternoon slate offered relief, with the 49ers handling the Dolphins (35-13), the Seahawks routing the Cardinals (31-7), and the Cowboys topping the Commanders (37-20).
Sky Sports